US Open 2025 Men’s Quarter-Final Previews

128 hopefuls began in New York 10 days ago, and just eight remain alive in their quest for the 2025 US Open title. With the final weekend drawing near, we preview each of the men’s quarter-finals, breaking down player form, betting odds and giving our predictions.

The year’s final Grand Slam has offered up a few surprises, with the likes of Felix Auger-Aliassime and Jiri Lehecka making impressive runs to the last eight. However, as with the previous three majors this season, there are a host of familiar faces too, with Jannik Sinner and Carlos Alcaraz looking ominous, while Novak Djokovic has again kept himself in the mix for Grand Slam number 25.

Will the US Open follow a similar script, or can one of the outside title contenders pull off a heist this week? Read on to find out our take.

Jannik Sinner vs Lorenzo Musetti

Two Italians meet in the top of the draw, with defending champion Sinner coming up against compatriot Lorenzo Musetti. The latter’s appearance in the quarter-finals is something of a surprise, given his woeful form leading into the tournament. However, a rekindling of sorts, plus the withdrawal of Jack Draper due to injury from this section have meant it’s another slam quarter-final for Musetti.

Seeing Sinner in the second week of the US Open is no surprise whatsoever though. The 24-year-old has gone about his business steadily so far, firing a warning shot most recently with a 6-1, 6-1, 6-1 dismantling of Alexander Bublik. He’s the heavy favorite to leave New York with the title, and for good reason.

Sinner vs Musetti prediction

No sane punter would bet against Sinner in this spot. He’s on a 25-match win streak on hard courts, leads the head-to-head against Musetti 2-0, and just blasted his way past one of the most dangerous men on Tour right now. Musetti is a good player, but isn’t at his best away from the natural surfaces. Despite picking up four wins so far at the US Open, he’s to face anyone of real caliber. Expect this one to be routine for Sinner.

Best bets on Sinner vs Musetti

Under 33.5 games @ 1.83 (-120)
Sinner to win 3-0 @ 1.80 (-125)
Sinner -6.5-game handicap @ 1.80 (-125)

Felix Auger-Aliassime vs Alex de Minaur

We expected Alex de Minaur to make his way through to yet another Grand Slam quarter-final, but Felix Auger-Aliassime being his opponent was not on our bingo card.

The Canadian has been mighty impressive in New York, bringing back shades of 2022 with his ruthless forehand and powerful serving. Remember, this is a player once touted as a future Grand Slam winner as recently as a few years ago. Auger-Aliassime hasn’t had it easy either, knocking off back-to-back seeds in Alexander Zverev and Andrey Rublev.

De Minaur has been a little more low profile, motoring through his first four matches without facing a seed and dropping just the one set. This means he’s relatively untested, but also has plenty of gas in the tank.

Auger-Aliassime vs De Minaur prediction

Form-wise, Auger-Aliassime is the pick here, but we just don’t trust him. For too long he’s promised a lot and fallen short. With a shot at making the semi-finals here, we expect his old ways of misfiring under pressure to show themselves again.

De Minaur is a consummate professional, and will be happy to weather the Auger-Aliassime storm with his gritty defense. This should be a good, old-fashioned battle, but our money is on De Minaur to come out on top.

Best bets on Auger-Aliassime vs De Minaur

De Minaur to win @ 1.61 (-163)
De Minaur to win 3-1 @ 4.00 (+300)
Over 39.5 games @ 1.83 (-120)

Novak Djokovic fighting for Grand Slam number 25

Novak Djokovic vs Taylor Fritz

Three things are sure in life: death, taxes and Djokovic making his way to the business end of Grand Slams in 2025. Despite having not played since Wimbledon, the greatest-of-all-time has still managed to string together four relatively easy wins and found himself a live chance at making yet another major semi-final. More on Djokovic and his current racquet.

All that stands in Djokovic’s way is the last American standing, Taylor Fritz. Fritz has had a patchy year, but has turned things around with a 25-5 run since the start of the grass season. This includes two titles and a Wimbledon semi-final, and now he’s out to defend his finalist points from last year.

Djokovic vs Fritz prediction

Many are touting this as Fritz’s biggest chance to gain a victory over Djokovic. While that may be true, let’s not forget the stark reality: the current head-to-head between these two players sits at 10-0 in Djokovic’s favor. Sure, Fritz has improved over the past three years, but this kind of one-sided history doesn’t simply disappear.

Djokovic has proven himself the third-best player in the world time and time again in 2025, and there’s no reason to believe he won’t do so again this week. Fritz will be competitive, but the Serbian isn’t missing his daughter’s birthday just to lose.

Best bets on Djokovic vs Fritz

Djokovic to win @ 1.57 (-175)
Djokovic to win 3-1 @ 4.00 (+300)
Over 0.5 tiebreaks @ 1.40 (-250)

Carlos Alcaraz vs Jiri Lehecka

An intriguing encounter awaits at the bottom of the men’s draw, with Alcaraz taking on Lehecka in a match we’ve seen twice already this year. The pair have split the two meetings, making this contest even more interesting.

So far in New York, Alcaraz has put together one of his best slam runs in recent memory, not dropping a set across four rounds. He’s looked locked in, hungry, and ready for a rematch with Sinner at the pointy end of the tournament. Lehecka has been impressive too, though sets have been dropped in the first, second and fourth rounds.

Alcaraz vs Lehecka prediction

Lehecka is one of the few players who can rush Alcaraz with his power-game from the baseline. In each of their last two meetings this has earned the Czech a set, gaining him victory in one. We expect a similar situation to unfold here: he’ll redline, dominate for periods, but ultimately be unable to maintain this level for long enough to win the match.