The draw for the 2025 U.S. Open is out and we’re awaiting to see if there are any surprise results coming up already in the first rounds of the tournament. Let’s look at the first round starting shortly, and the best matches to watch.
Which are the best US Open first round matches?
Men’s Singles
Carlos Alcaraz vs. Reilly Opelka
A great matchup right away: 2nd seed Alcaraz opens against the towering American, Reilly Opelka. Opelka’s booming serve (more on Opelka’s racquet) has proven dangerous, even top players expect a rough test right out of the gate. Expect the Spaniard to get the job done though.
Alexander Bublik vs. Marin Cilic
An entertaining showdown awaits as shot-maker Bublik takes on former US Open champion Cilic. With Cilic back on the big stage and Bublik’s recent form, this could be a dramatic first-round duel.
Lorenzo Musetti vs. Giovanni Mpetshi Perricard
Italy’s stylish Musetti faces the French powerhouse Mpetshi Perricard. It’s really style and flair versus firepower when Musetti’s finesse game is up against one of the ATP’s biggest serves.
Novak Djokovic vs. Learner Tien
Djokovic, aiming for a record 25th major, opens against US rising star Learner Tien. It could be a smooth entry or a stage for a fresh upset.

Women’s Singles
Coco Gauff vs. Ajla Tomljanovic
Might not seem like an interesting clash when Gauff faces the world no 84, but the Australian veteran has taken down big names before and her game really suits the hard-courts at the US Open. Will we see an upset here already?
Iga Swiatek vs. Emiliana Arango
Newly minted No. 2 seed Swiatek begins against Emiliana Arango as huge favorite of course. With form high after Cincinnati, we will watch closely for signs of momentum as she is now the odds favorite to win the event in New York.
Barbora Krejcikova vs Victoria Mboko
A clash of generations. Former French Open champion Krejcikova faces rising Canadian teenager Mboko, who has been tipped as one of the brightest prospects on tour.
Venus Williams vs. Karolina Muchova
A nostalgic yet high-stakes opener for Venus. At age 45, she returns to the US Open via wildcard to face 11th seed Muchova, an emotional and compelling matchup.
What match are you looking forward to most? Let us know in the comments. Check our recommended betting sites of you want to place a bet on the tournament.

